Giulia Longinotti

Giulia Longinotti

Company: Medigene Immunotherapies GmbH

Job title: Director TCR Discovery Platform


KRAS Mutation-Specific TCR-T Cells are Empowered for Improved Multi-Functionality & Durability by Inclusion of a Costimulatory Switch Protein 12:00 pm

Generation of 3S TCRs from naïve repertoires of healthy donors that recognize KRASspecific mutations (mKRAS) display high specificity, high sensitivity and an excellent safety profile in recognition of mKRAS-expressing tumour cells Co-expression of a PD1-41BB Costimulatory Switch Protein (CSP) armors TCR-T cells against PD-L1-mediated inhibition and enhances multiple cellular functions through intracellular activation of the…Read more

day: Day Two

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