First-In-Class Inhibitors of ERAP1 Generate Novel Targets for MHC-IDirected Therapies
Time: 10:20 am
day: Day One
Details:
- Inhibition of ERAP1 by first-in-class small molecule inhibitors significantly alters the antigenic repertoire of cancer cells
- Novel ERAP1-independent epitopes are presented on MHC-I molecules for immune recognition
- Cytotoxic T cell recognition of these novel epitopes mediates tumor cell lysis
