Discovering the Optimal Clinical Setting for Achieving Positive & Accurate Clinical Results to Streamline Candidate Approval
Time: 3:00 pm
day: Pre-Conference Day
Details:
To successfully carry out trials for neoantigen therapies, the field needs to understand what the best clinical setting is and what conditions should be used to get the most accurate and reliable results. This enables neoantigen therapies to be fast-tracked through the clinic in order to get to the patients in need faster.
- What learnings can be taken from the current clinical trials which have occurred with neoantigen therapies?
- How to design the optimal clinical conditions – low tumour burden vs high tumour burden, hot tumours vs cold tumours?
- What to do to maximize the chance of getting a signal?
- Analysing optimum clinical trial conditions for personalized vaccines and combination therapies.
- What is the process for registration in different regions?
- What learnings can be taken from the current clinical trials which have occurred with vaccine and neoantigen therapies?
- How to design the optimal clinical conditions – untreated vs pretreated, metastases stage/location/size, immune cell infiltration, ECOG status? What to do to maximize the chance of getting a signal?
