Reduction of Circulating Naïve Tregs & gMDSCs Mediated by NEO-201 & Low Levels of Soluble MICA are Prognostic Factors for Efficacy of Combined Treatment With NEO-201 & Pembrolizumab in Adults With Solid Tumours Resistant to Prior Checkpoint Inhibitors
Time: 4:30 pm
day: Day Two
Details:
- Examining the Accumulation of immunosuppressive cells in the TME, such as Tregs and gMDSCs is one of the mechanisms of tumour resistance to checkpoint inhibitors
- Understanding how NEO-201 mediates the killing of targets cells expressing core 1 O-glycans (including cancer cells and immunosuppressive cells) through ADCC and CDC. Elimination of circulating gMDSCs and Tregs mediated by NEO-201 may overcome resistance to checkpoints inhibitors
- Discussing levels of immunosuppressive cells and soluble factors that affect NK cells cytotoxic activity after treatment with NEO-201 can be used as prognostic factors for the efficacy of treatment with NEO-201 alone or in combination with other anti-cancer drugs
